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快速毒诊断的单独离心器

Mohammad Osaid¹, M Henar Marino Miguélez¹, Berke Bayrak¹

¹Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, 100 44, Sweden.

Advanced healthcare materials

|September 2, 2025

概括

在不到40分钟的时间内将血液样本中的细菌分离并集中. 这种败血症诊断创新显著缩短了病原体识别时间,

科学领域:

生物医学工程
临床诊断
微生物学

背景情况:

败血症是一种危及生命的疾病,死亡率高,因病原体识别和治疗的延迟而恶化.
目前的败血症诊断方法依赖于基于培养的长时间工作流程,延迟了几天的向治疗.

研究的目的:

开发和验证一个完全自动化的,插即用的离心管,用于直接从血液或血液培养物中快速分离和缩细菌.
为了更快地识别病原体,并支持关键性败血症诊断.

主要方法:

设计用于处理7.5毫升血液或血液培养样本的新型自动离心管.
使用常规实验室离心机在40分钟内隔离和缩细菌.
评估下游与隔离后培养策略,直接MALDI-TOF识别和微流体单细胞检测的兼容性.

主要成果:

在0.7毫升透明悬浮液中,在40分钟内,细菌度增加了3倍以上.
已经显示出超过99.9%的血细胞排斥.
支持检测低至10CFU/ml的细菌度,并使同一班次的细菌增强成为可能.

结论:

自动化管道平台提供了快速,高效的细菌度方法,显著减少了败血症的诊断时间.
与现有基础设施和下游应用程序的兼容性促进了改善败血症管理的临床采用.
这项创新有可能将毒症诊断时间缩短约一天.

关键词:

细菌没有血.血液中的感染诊断系统马尔迪托夫微流体感染性疾病

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