在基因相同的个体中基因表达的变化预测了繁殖特征
Amy K Webster1,2, John H Willis1, Erik Johnson1
1Institute of Ecology and Evolution, University of Oregon, Eugene, United States.
eLife
|September 2, 2025
概括
个体基因表达的差异,而不是遗传学,显著预测和影响相同生物的特征. 这项研究揭示了推动生物变异和特征结果的非遗传因素.
科学领域:
- 遗传学
- 发育生物学
- 分子生物学
背景情况:
- 全基因组关联研究 (GWAS) 解释了复杂特征的有限个体差异.
- 环境因素对特征病因有很大影响,甚至在基因相同的个体中也会造成变异.
- 区分遗传与环境因果关系是一项挑战.
研究的目的:
- 在没有遗传变异的情况下,研究基因表达的个体差异的基础.
- 确定导致特征变化的非遗传贡献的基因和机制.
- 评估基因表达在特征确定中的预测性和因果作用.
主要方法:
- 在180个基因相同的"Caenorhabditis elegans"中测量生殖特征.
- 在每个虫上进行单个转录.
- 操纵预测基因的mRNA水平和分析的染色体环境.
主要成果:
- 鉴定了数百个与生殖特征相关的表达变异的基因.
- 小基因组准确地预测了两个特征的变异性的一半和四分之一.
- 特定基因的因果作用和与染色体结构相关的表达变异 (H3K27三甲基化).
结论:
- 基因表达的个体,非遗传差异是特征的高度预测.
- 基因表达的变化是塑造生殖特性的原因.
- 染色体结构可能导致非遗传基因表达变异.
更多相关视频
10:08Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
Published on: August 12, 2019
17.3K
11:25Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
Published on: February 22, 2016
10.9K
相关概念视频
Genetic Variation
387
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
Genes exist in different versions called alleles,...
387
What is Population Genetics?
59.5K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
59.5K
Mutation, Gene Flow, and Genetic Drift
59.4K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
59.4K
Background and Environment Affect Phenotype
6.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.7K
Gene-Environment Interactions
433
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
433
Gene Flow
35.6K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.6K
