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Updated: Sep 9, 2025

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通过基于工程拉索的强有力的选择性双αvβ6/8抑制剂克服免疫检查点抑制剂的抵抗

Anna Lechner1, Peter A Jordan1, Gabriella Costa Machado da Cruz1

  • 1Lassogen, Inc., 3830 Valley Centre Drive, Suite 705-562, San Diego, California 92130, United States.

Journal of the American Chemical Society
|September 2, 2025
PubMed
概括

通过瘤微环境中向TGF-β,使用拉索设计的双整蛋白抑制剂可以克服免疫检查点抑制剂的耐药性. 在临床前的模型中,这种方法可以阻止瘤的生长和回归.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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