狼性炎患者的静脉血栓栓塞:频率和风险因素 - 一个队列研究
Fadi Kharouf1, Pankti Mehta1, Qixuan Li1
1University of Toronto Lupus Clinic, Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Rheumatology (Oxford, England)
|September 2, 2025
概括
静脉血栓栓塞 (VTE) 影响9. 3%的狼性炎 (LN) 患者. 在LN患者中,较高的疾病活性和蛋白尿是VTE的主要危险因素.
科学领域:
- 肝脏病学
- 关节病学
- 心血管医学
背景情况:
- 静脉血栓塞栓症 (VTE) 是系统性红斑狼 (SLE) 的一个已知的并发症.
- 只有有限的高质量的研究专门针对狼性炎 (LN) 的VTE.
研究的目的:
- 在被诊断为狼性炎的患者中确定VTE的发生频率.
- 确定该患者群体中导致静脉突发症的特定危险因素.
主要方法:
- 活检证明的LN患者的前性观察队列研究 (1970-2024年).
- 在LN发病后对静脉瘤事件进行纵向监测.
- 用于识别风险因素的时间变化的Cox比例危险模型,死亡作为竞争风险.
主要成果:
- 有324名LN患者的随访时间中位数为9. 9年.
- 在LN发病后的4. 4年内,VTE发生在9. 3%的患者中.
- 静脉突发症的独立危险因素包括较高的SLEDAI-2K评分和较高的蛋白尿水平.
结论:
- 这种严重的并发症可能发生在狼性炎的任何阶段.
- 疾病活动 (SLEDAI- 2K) 和蛋白尿是LN患者静脉瘤的主要危险因素.
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