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相关概念视频

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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相关实验视频

Updated: Apr 13, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
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在EGFR突变肺癌小鼠中,多次静脉移植人类带介质干细胞不会促进瘤发生.

Zepeng Zhang1,2, Anhua Xu1, Qian Zhou3

  • 1Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, People's Republic of China.

Stem cells translational medicine
|September 2, 2025
PubMed
概括

在新型异种移植模型中,重复移植人类带介质干细胞 (UC-MSC) 没有加速肺癌或促进前瘤环境. 这些发现表明UC-MSCs不会增加肺癌风险.

关键词:
欧洲粮食基金欧盟国家安全委员会癌症 癌症 癌症肺癌 肺癌异种移植

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科学领域:

  • 干细胞生物学
  • 癌症学
  • 免疫学

背景情况:

  • 介质干细胞 (MSC) 的治疗效果很有前途,但由于其免疫抑制和促血管性质,人们对潜在的瘤增生表示担忧.
  • 之前对MSC瘤原性安全性的研究产生了有争议的结果,通常使用免疫缺陷模型.
  • 需要强大的模型来评估MSC在正常免疫环境中的安全性.

研究的目的:

  • 研究人类带介质干细胞 (UC-MSC) 促进肺腺癌的潜力.
  • 评估重复UC-MSC移植对早期肺癌进展和瘤微环境的影响.
  • 在免疫能力强的异种移植模型中评估UC-MSCs的瘤性安全性.

主要方法:

  • 使用转基因小鼠开发了一种新型异种移植模型,该小鼠具有人类衍生的突变EGFR和功能性免疫系统.
  • 对UC-MSC进行重复静脉注射,以评估其对肺癌发生和进展的影响.
  • 分析了早期肺腺癌的持续时间,动态和病理特征.

主要成果:

  • 重复的UC-MSC移植并没有加速肺癌的发病.
  • 使用UC-MSC并没有增强支气管肺癌的进展.
  • 在UC-MSC移植后没有发现前瘤免疫微环境的证据.

结论:

  • 重复移植UC-MSC似乎不会增加肺癌的风险.
  • 这些发现支持UC-MSC在免疫能力模型中的肺癌发展的安全性.
  • 进一步的研究可以建立在这个模型上,以探索MSC在各种瘤环境中的安全性.