拉曼光谱和机器学习用于诊断乳腺癌
Sowndarya Rao1, Nikita Sharma1, Vyasraj G Bhat2
1Department of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Lasers in medical science
|September 2, 2025
概括
机器学习和拉曼光谱为早期发现乳腺癌提供了一种非侵入性的准确方法. 这种组合显示出高度的诊断准确性,
科学领域:
- 生物医学工程
- 医疗诊断
- 计算生物学
背景情况:
- 乳腺癌是全球女性的主要癌症,
- 传统的诊断方法,如乳房影像和活检,
- 早期发现可显著改善乳腺癌患者的治疗结果.
研究的目的:
- 审查机器学习 (ML) 和拉曼光谱 (RS) 结合用于乳腺癌诊断的有效性.
- 评估ML-RS技术的诊断准确性,敏感性和特异性.
- 在乳腺癌检测中确定RS-ML应用的挑战和未来方向.
主要方法:
- 使用PRISMA方法的系统文献审查.
- 纳入标准:2017-2024年间的研究,敏感度/特异性>80%.
- 对生物样本的RS数据应用的ML算法 (SVM,CNN,LDA) 的分析.
主要成果:
- 九项研究符合纳入标准,显示出高诊断性能.
- 结合RS-ML方法经常达到超过90%的灵敏度和特异性.
- RS-ML可用于分析各种生物样本 (组织,血清) 和实时应用.
结论:
- 与机器学习相结合的拉曼光谱为乳腺癌诊断提供了非常准确和非侵入性的方法.
- 这项RS-ML技术对手术期间和实时癌症评估具有前景.
- 需要进一步研究标准化框架,多中心验证和经济高效的技术开发.
相关概念视频
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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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