患有人格障碍的老年人的药物使用和生活质量
Julie E M Schulkens1,2, Sebastiaan P J van Alphen3,4, Lara Stas5
1Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands. Julie.schulkens@maastrichtuniversity.nl.
患有个性障碍的老年人经常使用许多药物,导致生活质量下降. 药物不良反应 (ADR), 不仅仅是药物数量, 显著影响他们的幸福感.
科学领域:
- 老年精神病学
- 临床药理学
- 医疗服务研究
背景情况:
- 增加精神病患者的药物使用,特别是那些有个性障碍的人.
- 患有PD的老年人面临更高的药物不良反应 (ADRs) 影响日常功能.
研究的目的:
- 描述患有PD的老年人与对照组之间的药物使用和与健康相关的生活质量 (HR-QOL).
- 在OA-PD中确定药物使用和HR-QOL的预测因素.
主要方法:
- 在77名OA-PD,54名PD成年人 (A-PD) 和88名健康老年人 (OA-H) 的截面研究中.
- 通过问卷和电子病历评估药物使用情况.
- 使用EQ-5D-3L (VAS和实用性得分) 测量HR-QOL.
主要成果:
- 多种药物 (≥5种药物) 影响了55. 8%的OA-PD.
- 他们比OA-H和A-PD使用更多的精神药物和体质药物.
- 与OA-H相比,OA-PD的EQ-VAS和EQ-实用性得分较低.
- 预测了HR-QOL的副作用,而不是药物数量.
结论:
- 在OA-PD中使用体质和精神药物的高患病率.
- 经过OA-PD报告的HR-QOL较低,可能由ADRs介导.
- 定期的药物审查对OA-PD至关重要;未来需要对抑郁症对HR-QOL的影响进行研究.
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