长非编码RNA的单个和组合独立预后生物标志物用于肝细胞癌
Long-Bin Jeng1,2,3,4, Horng-Ren Yang2,4, Chiao-Fang Teng5,6,7
1Organ Transplantation Center, China Medical University Hospital, Taichung, 404, Taiwan.
Discover oncology
|September 2, 2025
概括
长非编码RNAs (lncRNAs) 是预测肝细胞癌 (HCC) 预后的独立生物标志物. 本综述总结了支持 lncRNAs 早期鉴定和改善HCC患者的生存率的证据.
科学领域:
- 癌症学
- 分子生物学
- 遗传学
背景情况:
- 肝细胞癌 (HCC) 仍然是全球癌症相关死亡的主要原因,尽管治疗方面取得了进展.
- 确定预后生物标志物对于早期检测和针对性治疗HCC患者的结果至关重要.
- 通过调节瘤基因和瘤抑制剂,长非编码RNAs (lncRNAs) 参与HCC的发展.
研究的目的:
- 审查和总结有关长非编码RNA (lncRNA) 生物标记物的现有文献.
- 在肝细胞癌 (HCC) 中评估单个或组合的 lncRNA 生物标志物的独立预后值.
- 突出 lncRNAs 作为 HCC 患者预后预测工具的潜力.
主要方法:
- 在HCC预后中研究 lncRNA 的综合文献搜索.
- 支持 lncRNAs 作为独立预后指标的证据分析.
- 在单个和组合 lncRNA生物标记面板上的结合结果.
主要成果:
- 在HCC瘤组织和循环中经常观察到改变的lncRNA表达.
- 许多 lncRNA 已被证明是 HCC 的独立预后生物标志物.
- 结合lncRNAs可能为HCC结果提供更强的预测能力.
结论:
- lncRNAs是预测HCC预后的一类有希望的生物标志物.
- lncRNA生物标志物可以帮助早期识别高危HCC患者.
- 进一步验证 lncRNA生物标志物可以改善HCC的临床治疗和患者存活率.
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