生物活性基基基基基基基基基基基基 和 子 sp
Yu Wang1, Guang-Ping Cao1, Xin-Jian Qu2,3,1
1Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.
Journal of natural products
|September 2, 2025
概括
发现了三种新的真菌化合物和三种已知化合物. 一种化合物表现出强烈的抗良性前列腺增生 (BPH) 活性,而另外两种化合物表现出对癌细胞的弱细胞毒性.
科学领域:
- 自然产品化学
- 菌群学
- 药理学
背景情况:
- 来自红树林的真菌,特别是Aspergillus sp. 和Penicillium sp. 是生物活性二次代谢物的来源.
- 的共同培养可以导致新化学实体的发现.
研究的目的:
- 从真菌共同培养中分离和描述新的和已知的关节衍生物.
- 评估隔离化合物的抗菌作用,细胞毒性和抗良性前列腺增生 (BPH) 活性.
主要方法:
- 使用1H NMR引导分离的化合物的分离.
- 使用综合光谱分析 (1D/2D NMR,HRESIMS,ESI-MS/MS),马菲分析,DP4+概率和ECD比较进行结构阐明.
- 生物评估包括抗菌检测,针对MHCC-97H细胞的细胞毒性检测和抗BPH活性检测.
主要成果:
- 成功分离了三种新的关节衍生物 (1 - 3) 和三种已知的同源物 (4 - 6).
- 化合物1和5对MHCC-97H细胞具有较弱的细胞毒性,IC50值分别为20. 1±0. 9μM和25. 8±0. 4μM.
- 化合物4具有强烈的抗BPH活性,IC50值为0. 36±0. 02μM.
结论:
- 由红树林衍生而来的Aspergillus sp的共同培养 和Penicillium sp. 这两种植物. 产生了新的和已知的关节衍生物.
- 化合物4是作为抗BPH剂进一步研究的有希望的候选物.
- 化合物1和5需要进一步研究其潜在的细胞毒性作用.
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