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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
口腔状细胞癌中的微转移和分离瘤细胞:利用新兴技术完善节点分期

口腔状细胞癌中的微转移和分离瘤细胞:利用新兴技术完善节点分期

Sreeram Mp ¹, Karthik N Rao ², Lester D R Thompson ³, Juan Pablo Rodrigo ⁴, Remco de Bree ⁵, Göran Stenman ⁶, Clare Schilling ^7,8, Alessandra Rinaldo ⁹, K T Robbins ¹⁰, Alfons Nadal ¹¹, Abbas Agaimy ¹², Roderick H W Simpson ¹³, Alfio Ferlito ¹⁴

Sreeram Mp ¹, Karthik N Rao ², Lester D R Thompson ³

¹Department of Head and Neck Oncology, Sri Shankara Cancer Hospital and Research Centre, Bangalore, India. drsreeram111@gmail.com.
²Department of Head and Neck Oncology, Sri Shankara Cancer Hospital and Research Centre, Bangalore, India.
³Head and Neck Pathology Consultations, Woodland Hills, CA, USA.
⁴Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
⁵Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
⁶Department of Laboratory Medicine/Pathology, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
⁷Head and Neck Academic Centre, UCL, London, UK.
⁸Department of Head and Neck Surgery, UCLH, London, UK.
⁹ENT Unit, Policlinico Città Di Udine, Udine, Italy.
¹⁰Department of Otolaryngology Head Neck Surgery, SIU School of Medicine, Southern Illinois University, Springfield, IL, USA.
¹¹Pathology Department, Department of Clinical Fundamentals, Universitat de Barcelona, IDIBAPS, Clínic Barcelona, Barcelona, Spain.
¹²Institute of Pathology, Comprehensive Cancer Center (CCC) Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
¹³Department of Pathology, University of Calgary, Calgary, AB, Canada.
¹⁴Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

⁰Department of Head and Neck Oncology, Sri Shankara Cancer Hospital and Research Centre, Bangalore, India. drsreeram111@gmail.com.

Head and Neck Pathology +

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2025年九月2日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

哨戒淋巴结活检 (SLNB) 有助于检测早期的口腔癌转移. 改善微转移和孤立瘤细胞 (ITC) 的检测对于完善分期和个性化治疗至关重要.

科学领域

癌症学
头部和部手术
病理学

背景情况

宫淋巴结转移是口腔状细胞癌 (OSCC) 的关键预后因素.
哨兵淋巴结活检 (SLNB) 是检测亚临床转移,包括微转移和孤立瘤细胞 (ITC) 的最小侵入性技术.
在OSCC中微转移和ITC的临床意义需要进一步定义.

研究的目的

审查OSCC中微转移和ITC的生物学意义,诊断挑战和新兴检测策略.
探索这些发现在完善OSCC分期和处理算法的潜在作用.

主要方法

专注于OSCC中的SLNB的综合文献审查.
对遗传病理检测技术,分子标记,人工智能 (AI) 和放射学进行检测.

主要成果

在某些地区,SLNB已被批准用于早期的OSCC,但将微转移和ITC数据纳入分期是不一致的.
孤立的瘤细胞 (ITC) 可能代表早期的转移,预后影响可变.
先进的技术 (例如免疫组织化学,分子诊断,人工智能辅助病理学) 显示出改善检测的希望,但缺乏强大的前性数据和管理共识.

结论

在OSCC中精确识别微转移和ITC是头部和部瘤学的发展领域.
未来的分期系统应该将这些发现纳入标准化协议和强有力的证据.
整合人工智能,分子诊断和放射学可以提高OSCC患者的风险分层和个性化治疗决策.

关键词:

人工智能孤立的瘤细胞淋巴结淋巴细胞映射微转移分子检测口腔新生体新生体隐藏的转移口腔状细胞癌预测标志物辐射学护卫淋巴结活检

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