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  1. 首页
  2. 在新辅助疗法后预测乳腺癌收缩模式的内微生物组相关mri模型
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  2. 在新辅助疗法后预测乳腺癌收缩模式的内微生物组相关mri模型

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在新辅助疗法后预测乳腺癌收缩模式的内微生物组相关MRI模型

Yuhong Huang1, Xinyang Song2, Yilin Chen1

  • 1Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan 2nd Rd, Yuexiu District, Guangzhou 510080, China.

Radiology
|September 2, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

这项研究开发了一种整合内微生物组数据的MRI模型,用于预测乳腺癌患者在新辅助治疗后的瘤缩模式,从而改善手术规划.

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科学领域:

  • 癌症学
  • 放射学
  • 微生物组研究

背景情况:

  • 在新辅助疗法 (NAT) 后准确预测瘤缩模式对于乳腺癌手术规划至关重要.
  • 内微生物组影响治疗反应,这表明其成像特征可以提高TSP预测.

研究的目的:

  • 开发和验证一个包含内微生物组数据的MRI模型,以便在NAT后准确预测TSP.
  • 评估模型在不同分子亚型和瘤阶段的性能.

主要方法:

  • 对12所医院的2249名乳腺癌患者进行了回顾性分析.
  • 使用3DU-Net细分,放射性/深度学习特征 (ResNet-50) 和微生物组数据开发五种MRI模型.
  • 使用培训,内部和外部数据集与ROC曲线和诊断指标进行验证.

主要成果:

  • 与单次点模型相比,融合模型在预测TSP方面表现优异 (内部和外部验证时AUC为0. 89和0. 87).
  • 该模型显示了多种分子亚型和瘤阶段的稳定性.
  • 同心收缩与内微生物群的增加有关.

结论:

  • 整合内微生物组信息的MRI模型能够准确预测瘤缩模式.
  • 这种方法有望在接受NAT的乳腺癌患者中优化乳腺保护手术规划.