儿童不良经历评分与创伤性脑损伤发生之间的关联:系统性审查和元分析
Jenney Zhu1,2, Maya A C MacIsaac-Jones1,2, Serena Jenkins1,2
1Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
Journal of neurotrauma
|September 2, 2025
概括
不良的童年经历显著增加了创伤性脑损伤 (TBI) 的可能性. 这一元分析发现了很大的积极关联,强调了需要基于创伤的TBI预防策略.
科学领域:
- 神经科学
- 公共卫生
- 心理学
背景情况:
- 童年不良经历和创伤性脑损伤是全球普遍存在的问题.
- ACE和TBI都与不良的长期健康结果有关.
- 关于ACE与TBI的研究结果不一致.
研究的目的:
- 系统地审查和分析ACE和TBI发生之间的关联.
- 调查ACEs-TBI关系的潜在调节因素 (年龄,性别,位置).
主要方法:
- 通过PsycINFO,MEDLINE,Embase和CINHAL (1998-2024) 的系统文献搜索.
- 包括测量ACE和TBI发生率的研究.
- 8项研究的随机效应多层次元分析 (10个样本,N=4954).
主要成果:
- 在ACE得分和TBI发生之间发现了显著的,很大的正相关性 (r=0.31, p < 0.001).
- 具有较高ACE分数的个体更有可能经历TBI.
- 调节者分析没有发现显著的改变因素.
结论:
- 较高的ACE得分与TBI发生率的增加密切相关.
- 调查结果强调需要在TBI预防和护理方面采用综合创伤方法.
- 解决童年逆境可能会减轻创伤风险及其后果.
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