病毒感染中的不适应性训练免疫力
Dmitri Sviridov1,2, Mihai G Netea3,4, Michael I Bukrinsky5
1Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
The Journal of clinical investigation
|September 2, 2025
概括
训练免疫 (TRIM) 是免疫细胞的重编程,可以保护或有害. 环境因素, 而不是特定的触发因素, 决定TRIM是否变得不适应, 导致慢性疾病.
科学领域:
- 免疫学
- 细胞生物学
- 表观遗传学
背景情况:
- 训练免疫 (TRIM) 涉及长期的天生的免疫细胞的功能重编程.
- 最初在骨髓细胞中观察到的TRIM现在在非骨髓细胞,如内皮细胞和质细胞中被识别.
- 也可能导致慢性炎症和疾病.
研究的目的:
- 审查病毒诱导的训练免疫力.
- 探索TRIM的微生物,代谢和内生诱导因素.
- 讨论导致TRIM适应不良的因素及其在全身疾病中的作用.
主要方法:
- 对TRIM启动配体和受体的检查.
- 相关信号和表观遗传途径的剖析.
- 对骨髓中的TRIM诱导和各种细胞类型的参与进行审查.
主要成果:
- 不适应性TRIM是由情境因素 (刺激持久性,剂量,微环境,炎症) 而不是特定的分子事件引起的.
- 二次挑战的性质会影响TRIM反应的适应性或不适应性.
- 有关记忆的行为.
结论:
- 适应不良的TRIM有助于系统性疾病,包括动脉样硬化,糖尿病,败血症,癌症和自身免疫.
- TRIM会影响病毒对疫苗的反应.
- 提出了重定向适应不良的TRIM和未来研究问题的策略.
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