心血管指数与心力衰竭结果之间的关联:来自前多中心队列的见解
Toru Miyoshi1, Kohji Shirai2, Shigeo Horinaka3
1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
JACC. Advances
|September 2, 2025
概括
高心血管指数 (CAVI) 独立预测心力衰竭住院和心血管死亡. 这种动脉硬性标记在风险成年人中略有改善了风险预测.
科学领域:
- 心血管医学
- 预防性心脏病学
- 生物标志物研究
背景情况:
- 心力衰竭 (HF) 是一个严重的公共卫生挑战,预后不佳.
- 动脉硬是导致HF的一个因素,通过心脚血管指数 (CAVI) 进行评估.
- 在HF患者中CAVI的预后值需要进一步澄清.
研究的目的:
- 确定CAVI是否可以独立预测与HF相关的住院病例.
- 评估CAVI是否除已确定的心血管风险因素之外具有预后价值.
主要方法:
- 对前性CAVI- J研究的一项子分析包括2932名患有心血管风险因素的日本成年人 (40-74岁).
- 参与者按CAVI分层,平均持续时间为4. 9年.
- 考克斯比例危险模型和重新分类指数评估了HF住院和心血管死亡的风险和增量预后价值.
主要成果:
- 高CAVI (≥9. 0) 与主要结局风险增加3. 18倍独立相关 (P=0. 034).
- 将CAVI添加到传统风险模型中显著改善了风险预测 (全球基平方增加从8.82到18.77,P=0.002).
- 净重新分类指数为0. 621 (P<0. 001),表明预测准确度有所提高.
结论:
- 升高的CAVI是HF住院和心血管死亡的独立预测因素.
- 在患有心血管风险因素的个体中,CAVI比传统的风险预测略有提高.
- 需要进一步的研究,以充分确定CAVI在HF风险分层中的临床效用.
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