整合性基因组学和表型分析揭示了乳植物菌 BGI-N6 作为皮肤学益生菌开发的多功能候选物
Jinhong Wang1,2, Xiaowei Xu3, Yangfeng Wen1,4
1BGI Research, Shenzhen, China.
概括
乳植物菌植物BGI-N6在皮肤健康应用方面具有显著的潜力. 基因组和体外研究显示它具有抗氧化,抗微生物和抗衰老特性,支持其作为益生菌和后生物的使用.
科学领域:
- 微生物学
- 基因组学
- 皮肤病学
背景情况:
- 益生菌和后生菌对皮肤健康有好处.
- 完整的基因组分析对于了解微生物功能至关重要.
- 乳植物菌植物 BGI-N6 (BGI-N6) 被选为调查.
研究的目的:
- 探索BGI-N6的皮肤促进潜力.
- 整合基因组和表型分析进行BGI-N6表征.
- 在皮肤健康应用中建立BGI-N6的理论基础.
主要方法:
- 高精度的BGI-N6全基因组测序
- 与发酵,耐受性和适应性相关的基因分析.
- 在体外对抗氧化剂和抗菌活性进行表型评估.
- 对BGI-N6对皮肤损伤酶的影响的评估.
主要成果:
- BGI-N6基因组 (3,257,641 bp, 45% GC, 3030 CDS) 含有细菌素,抗氧化剂和有机酸生产的基因.
- 与L. plantarum 299v相比,BGI-N6具有更强的抗氧化活性.
- BGI- N6有效抑制了皮肤病原体的生长和抑制了原酶/ 弹性酶的活性.
- 乳酸和氨酸等生物活性化合物被确定为主要贡献者.
结论:
- 综合基因组和体外数据支持BGI-N6的皮肤健康益处.
- 在皮肤学应用中,BGI-N6具有显著的益生菌和后生菌潜力.
- 根据其已证明的能力,需要进一步开发BGI-N6用于皮肤健康.
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