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Updated: Jun 16, 2026

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在Talaromyces marneffei感染中的AST升高背后的PANoptosis介导机制

Wudi Wei1, Baili Zhan1, Lixiang Chen2

  • 1Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Guangxi. China.

PLoS neglected tropical diseases
|September 2, 2025
PubMed
概括

塔拉罗米切斯马尔内菲感染通过触发PANoptosis介导的肝细胞死亡和炎症来提高阿斯巴酸氨酸酶 (AST). 在艾滋病毒患者中,AST可帮助诊断和监测塔拉罗米科斯.

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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The pathophysiology of pneumonia involves the following steps:
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Critical processes in asthma pathophysiology include:
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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...