在低收入和中等收入国家怀孕期间补充低剂量:成本效益分析
Happiness P Saronga1, Pratibha Dwarkanath2, Hening Cui3
1Department of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
PLOS global public health
|September 2, 2025
概括
在低收入和中等收入国家,低剂量补充是预防妊娠前和早产的有效策略. 这种干预为卫生系统带来了显著的健康效益和成本节约.
科学领域:
- 产科和妇科
- 公共卫生
- 健康经济学
背景情况:
- 世卫组织建议孕妇高剂量 (每天1500-2000毫克),以减少妊娠前和早产的风险.
- 许多国家的高剂量补充剂的遵守和成本限制.
- 低剂量 (500毫克/天) 的疗效与高剂量补充剂相似.
研究的目的:
- 在低收入和中等收入国家 (LMICs) 评估低剂量补充剂的成本效益.
- 从卫生系统的角度估计对健康结果和成本的影响.
主要方法:
- 较低剂量补充与不补充的数学建模分析.
- 估计终身健康结果 (病例,死亡,避免的DALY) 和成本 (2022美元).
- 分析包括避免妊娠前和早产护理所带来的成本节约.
主要成果:
- 低剂量可以预防130万例早产和180万例子宫前.
- 预计这项干预措施将避免590万个因残疾而调整的寿命年 (DALY).
- 干预成本为2.67亿美元,节约成本为5.6亿美元,每DALY的增加成本为90美元.
结论:
- 在大多数LMIC中,孕期低剂量补充是非常具有成本效益的干预措施.
- 在129个模拟国家中,该干预措施显示出强的投资回报,并且在119个国家中具有成本效益.
- 这些发现支持将低剂量补充剂纳入LMIC的常规产前护理.
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