在COPD患者中使用多种药物:范围审查
Henil Upadhyay1, Fabbiha Akter2, Alexandros Koumides3
1The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|September 2, 2025
概括
在慢性阻塞性肺病 (COPD) 患者中使用多种药物很常见,增加了伤害风险. 定义各不相同,使得对COPD治疗中的药物相关问题的理解和管理变得复杂.
科学领域:
- 肺病学
- 临床药房
- 老年病学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的全球健康问题.
- 患有COPD的患者通常需要多种药物来治疗他们的病情和并发症.
- 这增加了多种药物和相关患者伤害的风险.
研究的目的:
- 确定COPD患者多药性的流行情况.
- 突出现有文献中多药学的多种定义.
- 在COPD中报告与药物相关的危害.
主要方法:
- 一项对28项研究的系统审查,报告了COPD人群中的多药性病例.
- 来自不同地理和临床环境的研究分析.
- 对多种药物的不同定义 (≥3至≥20种药物) 的检查.
主要成果:
- 在COPD中,多药性率从3. 9%到81. 4%不等,高多药性 (≥10种药物) 从6. 6%到74. 6%不等.
- 缺乏一致的多药性定义 (在46. 3%的研究中使用了5种药物) 阻碍了直接比较.
- 在不同国家和医疗保健机构中观察到多种药物的普遍性有显著的变化.
结论:
- 多药性在COPD患者中很常见,但由于定义和方法不一致,人们对其了解甚少.
- 慢性肺炎的多病性增加了对多种药物的不良影响的脆弱性,例如不良粘附性和药物相互作用.
- 临床医生必须考虑患者的年龄,并发症和药物相互作用,以减轻COPD患者的危害.
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