短时间静脉注射β-乳酸药物治疗住院患者的无并发性囊炎
Payton Simpson1, Katie Wallace1,2, Katherine Olney1,2
1Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|September 2, 2025
概括
在入院患者治疗急性无并发性囊炎时,静脉注射β- 乳酸抗生素3天疗程与较长疗程一样有效. 这种较短的持续时间,与口服过渡,为无并发性尿路感染 (UTI) 提供了可行的替代方案.
科学领域:
- 传染性疾病
- 药理学
- 尿道病学
背景情况:
- 当前美国传染病学会 (IDSA) 的指导方针建议在其他药物不可行的情况下,在不复杂的尿路感染 (UTI) 治疗中使用口服β- 乳疗程3 - 7天.
- 关于静脉注射 (IV) β - 乳糖剂对急性无并发性囊炎的疗效的数据有限.
- 最近的研究表明,较短的抗菌疗程可能对急性无并发性囊炎有效.
研究的目的:
- 评估短疗程 (≤3天) 与较长疗程 (≥4天) 的β-乳酸抗生素对急性无并发性囊炎的非劣势.
- 为了比较短时间和长时间的β-乳糖治疗失败率.
- 评估二次结果,包括Clostridioides difficile感染,重新入院和门诊接触.
主要方法:
- 单中心,回顾性,非劣势队列研究.
- 包括急性无并发性囊炎住院的成年患者.
- 患者接受了≤3天的β- 乳酸抗生素 (至少1天IV) 或≥4天的β- 乳酸抗生素.
主要成果:
- 包括52名患者,其中33名为短期治疗组,19名为长期治疗组.
- 治疗失败率相似:短疗程组中的15. 2%,长疗程组中的15. 8% (p=1,000).
- 塞夫特里亚是最常见的抗生素;平均总持续时间为3天 (短) 和6天 (长) (p< 0. 001).
结论:
- 对于住院患有急性无并发性囊炎的患者,可以考虑进行三天的贝塔乳治疗,包括静脉注射,然后进行口服.
- 在这种患者群体中,较短的β- 乳疗程的疗效与较长的疗程相美.
- 这种方法可能为需要初始静脉治疗的无并发性尿路感染提供更简单的治疗选择.
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