靠近危险废物热处理设施改变人类生理:社区驱动的试点研究
Avinash Kumar1,2, Chuqi Guo3, Qudus Sarumi4
1Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States.
Experimental biology and medicine (Maywood, N.J.)
|September 2, 2025
概括
暴露于科尔法克斯热处理设施的排放可能会影响人类健康. 附近居民呈现高氧化应激标志物和改变的代谢途径,
科学领域:
- 环境健康
- 代谢学
- 毒理学
背景情况:
- 开放式燃烧/开放式爆炸 (OB/OD) 是一种释放有害污染物的爆炸性废物处理方法.
- 路易斯安那州的科尔法克斯热处理 (TT) 设施是该国唯一的商业OB/OD站点,引发了环境和公共卫生问题.
- 了解TT设施排放对健康的影响对于社区的福祉至关重要.
研究的目的:
- 调查TT设施附近居民的代谢变化.
- 确定暴露在TT排放中的潜在生物标志物.
- 探索近距离关系,性别,种族和代谢变化.
主要方法:
- 对51名当地居民的尿样进行非向的代谢学分析.
- 超高性能液体染色学与高分辨率质谱学 (UHPLC-HRMS) 结合用于代谢物识别.
- 基于邻居,性别和种族的代谢物概况进行统计分析.
主要成果:
- 鉴定了217种代谢物,因其靠近TT设施而存在显著差异.
- 较近居民的氧化应激标志物 (例如,谷硫胺) 和氧化还原平衡变化 (GSH/GSSG比).
- 关键代谢途径的干扰,包括能量代谢,氨基酸代谢,糖解和酸循环.
结论:
- 接触TT设施的排放与附近居民的代谢中断和氧化应激增加有关.
- 代谢特征因性别和种族而异,这表明内在因素和环境因素之间存在复杂的相互作用.
- 需要进一步研究以确定长期的健康影响,并制定缓解策略.
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