乳糖与PEG结合在结肠镜前进行有效和安全的肠道准备:一个元分析
Hu-Bin Xia1,2,3,4,5, Wen-Li Ruan1,2,3,4,5, Min Wu6
1The Fourth School of Clinical Medicine Zhejiang Chinese Medical University, Hangzhou First People's Hospital Hangzhou, Zhejiang China.
JGH open : an open access journal of gastroenterology and hepatology
|September 2, 2025
概括
与单独使用PEG相比,将聚乙烯糖醇 (PEG) 电解液与乳糖相结合可显著改善肠道对结肠镜的准备. 这种增强的治疗方案还减少了不良事件,并增加了腺瘤检测率.
科学领域:
- 胃肠病学
- 内镜检查
- 药理学
背景情况:
- 有效的肠道准备对于成功的结肠镜检查和精确的腺瘤检测至关重要.
- 通常使用聚乙烯糖醇 (PEG) 电解液,但其有效性可以提高.
研究的目的:
- 在结肠镜检查中比较PEG与乳糖结合的疗效与PEG单独的疗效.
- 评估两种疗法之间不良反应和腺瘤检测率的差异.
主要方法:
- 一项针对2468名参与者进行的16项符合条件的研究的系统审查和元分析.
- 在主要数据库 (PubMed,Embase,Cochrane图书馆等) 进行文献搜索. ) 的情况.
- 使用波士顿肠道准备量表 (BBPS) 评分和腺瘤检测率评估肠道准备质量.
主要成果:
- 与单独使用PEG相比,PEG与乳糖的结合显示出更高的肠道清洁效果 (OR=3. 57) 和更高的BBPS分数 (SMD=0. 38).
- 组合治疗显著降低了吐 (OR=0. 54),腹痛 (OR=0. 54) 和胀气 (OR=0. 53) 的发生率.
- 使用PEG加乳糖 (OR=2. 57) 显著改善了腺瘤检测率,恶心或重复检查的意愿没有显著差异.
结论:
- 结合PEG和乳糖是比单独使用PEG更有效的肠道准备策略.
- 这种疗法增强了清洁,增加了腺瘤检测,并降低了不良事件的发生率.
- 在结肠镜检查之前,建议使用乳糖的PEG进行最佳的肠道准备.
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