在化疗后患有肺癌的患者中神经血管合的破坏
Lanyue Hu1, Shaohua Ding2, Jun Yao1
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Quantitative imaging in medicine and surgery
|September 2, 2025
概括
在非小细胞肺癌患者中,化疗会改变神经血管合 (NVC),影响认知功能. 这项研究揭示了与化疗相关的认知障碍 (CRCI) 相关的神经血管脱.
科学领域:
- 神经科学
- 癌症学
- 放射学
背景情况:
- 与化疗相关的认知障碍 (CRCI) 在非小细胞肺癌 (NSCLC) 患者中很常见.
- 认知缺陷可能源于神经元活动和脑血流 (CBF) 的改变.
- 化疗后神经血管合 (NVC) 变化的具体影响尚不清楚.
研究的目的:
- 在化疗后研究NSCLC患者的NVC变化.
- 为了将NVC变化与神经认知功能障碍相关联.
主要方法:
- 43名NSCLC患者 (20名接受化疗[CT(+) ],23名未接受化疗[CT(-)) 接受了pCASL,rs- fMRI和认知测试.
- 全球和区域NVC指数是使用CBF,ALFF和ReHo计算的.
- 统计分析比较了群体,并评估了NVC认知表现关系.
主要成果:
- CT(+) 组的CBF-ALFF和CBF-ReHo相关性显著较低.
- 区域分析显示CT(+) 组的特定大脑区域的CBF:ALFF和CBF:ReHo比率发生变化.
- 在右MFG和左副海马区域的认知分数 (MoCA,记忆) 和CBF:ALFF比率之间发现了负相关性.
结论:
- 在NSCLC患者中,化疗诱导神经血管脱.
- 多模式神经成像 (rs-fMRI,pCASL) 可以揭示CRCI的神经基础.
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