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Updated: Sep 9, 2025

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基于F-FDG PET/CT的手术前全损伤糖解和淋巴血管侵袭之间的相关性及其在初级胃癌中的预测价值:一个横截面研究

Xiu-Qing Xue^1,2, Xiao-Feng Li³, Xun Shi^1,2

¹Department of Nuclear Medicine, The First People's Hospital of Yancheng, Yancheng, China.

Quantitative imaging in medicine and surgery

|September 2, 2025

概括

使用18F-FDG PET/CT测量的手术前全损伤糖解 (TLG) 是胃癌中淋巴血管侵袭 (LVI) 的一个有价值的预测指标. 较高的TLG值与增加的LVI风险相关,有助于风险评估.

科学领域:

癌症学
核医学
放射学

背景情况:

淋巴血管侵袭 (LVI) 是胃癌转移的一个关键因素.
准确预测LVI对于治疗规划和预后至关重要.
18F-FDG PET/CT提供可以预测LVI的代谢信息.

研究的目的:

评估术前全损伤糖解 (TLG) 与胃癌中的LVI之间的相关性.
使用18F-FDG PET/CT评估TLG对LVI的预测值.

主要方法:

对177名胃癌患者的18F-FDG PET/CT数据进行了回顾性分析.
分析包括TLG,SUVmax,SUVmean和MTV等代谢参数.
用物流回归和ROC曲线来评估TLG的相关性和LVI的预测效果.

主要成果:

在较高的TLG和增加的LVI风险之间发现了显著的关联 (OR/ SD: 1. 428, P=0. 039).
在预测LVI方面,TLG的灵敏度很高,特别是在cLNM小组 (82. 1%).
特定的TLG值预测了各个子组的敏感性和特异性.

结论:

手术前的TLG是评估胃癌LVI风险的有价值的成像生物标志物.
TLG与LVI风险呈现正线性相关性.
在临床淋巴结转移负面的患者中,TLG对于识别LVI特别有用.

关键词:

胃癌淋巴血管侵袭 (LVI)定子发射断层扫描 (PET)整体病变糖解 (TLG)

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