克罗恩病和腹部疼痛患者的异常结构变化和功能连接障碍:基于声素的形态测量和功能磁共振成像研究
Xinyan Wu1,2, Ling Yang2, Li Yu2,3
1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Quantitative imaging in medicine and surgery
|September 2, 2025
概括
克罗恩病的疼痛会改变大脑的结构和连接性, 这些变化为克罗恩病患者内脏疼痛的神经基础提供了新的见解.
科学领域:
- 神经成像
- 胃肠病学
- 精神病学
背景情况:
- 腹部疼痛是克罗恩病 (CD) 的常见和致残症状.
- 与CD相关的腹痛的神经基础尚不清楚.
- 识别与CD疼痛相关的大脑变化对于开发向治疗至关重要.
研究的目的:
- 在CD患有腹痛的患者中研究大脑结构变化和功能连接 (FC).
- 将CD和疼痛患者的脑形态和CF与CD但没有疼痛患者和健康对照者的脑形状进行比较.
- 探索大脑变化与临床疼痛测量之间的关系.
主要方法:
- 从23名疼痛CD患者,24名非疼痛CD患者和25名健康对照患者中使用3DT1权重和静止状态功能性MRI扫描 (fMRI).
- 使用基于声素的形态测量来分析灰色物质体积 (GMV) 的差异,并对FC比较进行共变性分析.
- 进行偏差相关分析以将GMV和FC变异与临床评估联系起来.
主要成果:
- 与HC和非疼痛CD患者相比,疼痛CD患者在右侧前带皮层 (ACC) 和轨道前区域显示出改变的GMV.
- 在非疼痛CD患者和HC患者的海马体中观察到GMV的增加.
- 在疼痛CD患者的右侧ACC和默认模式网络 (DMN) 之间,以及在疼痛CD患者的左侧轨道前皮层 (ORBmid) 和疼痛处理中心之间发现了增强的FC.
结论:
- 疾病的疼痛与大脑形态和功能的明显变化有关,特别是涉及ACC和轨道前皮层.
- 在ACC和DMN之间增加的FC,以及在轨道前端 - thalamic电路内,为CD中的内脏疼痛机制提供了新的神经成像证据.
- 这些发现凸显了大脑在克罗恩病中处理和调节疼痛的作用.
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