虚拟关节置换状态的膝关节的软骨损失大于没有
Felix Eckstein1,2, Wolfgang Wirth1,2, Ali Guermazi3
1Research Program for Musculoskeletal Imaging, Center for Anatomy and Cell Biology, and Ludwig Boltzmann Institute of Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University (PMU) Salzburg, Austria.
Osteoarthritis and cartilage open
|September 2, 2025
概括
临近虚拟膝关节置换的膝关节比对照组早两年显著地损失了软骨. 这种软骨损失与更糟糕的临床结果有关,这表明它对膝盖健康的预测价值.
科学领域:
- 骨科和体育医学
- 放射学
- 生物医学工程
背景情况:
- 膝关节关节炎通常会导致严重的疼痛和生活质量下降.
- 预测膝关节关节炎的进展和需要手术干预,如膝关节置换,仍然是一个临床挑战.
- 由患者报告的结果定义的虚拟膝关节置换 (vKR) 状态为临床进展提供了潜在的替代品.
研究的目的:
- 调查膝关节软骨损失的速度是否在临床虚拟膝关节置换 (vKR) 状态和需要手术的可能性较低的膝关节之间有所不同.
- 确定早期的软骨损失是否预示着vKR状态的发展.
主要方法:
- 一组膝盖被分为vKR病例 (根据疼痛和生活质量标准进行手术膝盖置换的最高10%的概率) 和vKR对照 (最低20%的概率).
- 根据性别,年龄和基线放射状况,在60个月后满足vKR状态的膝盖与对照组相匹配1:1.
- 在60个月的随访之前,使用MRI测定了中侧骨和大腿软骨厚度,最多每年进行5次检查.
主要成果:
- 与对照组相比,被归类为vKR病例的膝盖在达到vKR状态前两年表现出显著更大的中枢骨骨厚度损失 (-151 ± 337 μm vs. -38 ± 249 μm).
- 在vKR病例中,较大的软骨损失概率为1. 95 (95% CI: 1. 23-3. 08).
- 在维护或改善症状的vKR膝关节 (vKR+/+) 和没有 (vKR+/-) 的膝关节之间没有观察到软骨损失的显著差异.
结论:
- 根据患者报告的临床标准,在达到vKR状态的膝盖中,与vKR对照组相比,发现了较大的软骨损失.
- 这种关联是独立的,不管在以后的年度访问中是否保持vKR地位.
- 这些发现表明,增加膝关节软骨损失可能与更差的临床结果有关,并且vKR标准可能有价值,用于探索与其他结构成像评估的关系.
相关概念视频
Knee Joint
2.2K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
2.2K
Growth of Cartilage and Bone Tissue
3.5K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.5K
Development of the Limb Synovial Joints
1.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.5K
Bones of the Lower Limb: Femur and Patella
2.9K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
2.9K
Ankle Joint
1.8K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.8K
Structural Joints: Cartilaginous Joints
2.6K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.6K


