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肠移植中的出血和血栓形成;来自145次连续成年人移植的数据
Francesca Reeder1, Jessica Griffin1, Matthew Carter1
1Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Research and practice in thrombosis and haemostasis
|September 2, 2025
概括
接受肠移植的人面临高出血和血栓形成的风险. 直接口服抗凝剂 (DOAC) 在选定的患者中表现有前途,但对于这些复杂病例需要进一步的多中心研究.
科学领域:
- 移植手术
- 血管外科
- 胃肠病学
背景情况:
- 成人肠道/多器官移植服务管理有复杂血栓病史的患者.
- 肠道移植后的患者有明显的出血和血栓形成的风险.
研究的目的:
- 检查肠移植后的出血和血栓并发症.
- 为了评估急性腹部血管灾难的肠道移植.
- 评估肠道移植后使用直接口服抗凝剂 (DOAC).
主要方法:
- 从2007年到2023年6月在英国的一个中心对肠道移植患者的回顾性分析.
- 收集移植前血栓病史,手术并发症和移植后出血/血栓病率的数据.
- 对因腹部血管灾难而接受移植的患者和接受DOAC治疗的患者的结果的综述.
主要成果:
- 在138名接受者中,70%的患者在移植前有血栓形成史;4%的患者经历了手术内血栓形成.
- 移植后 (+2至+92) 日发生38%的严重出血和26. 1%的血栓形成.
- 八名血管灾难的救援移植有良好的结果;五名接受DOAC的患者没有出现并发症.
结论:
- 肠移植患者很容易发生移植后出血和血栓形成.
- 肠子移植是急性腹部血管灾难的可行的救援疗法.
- 直接口服抗凝剂 (DOAC) 可以安全地用于部分移植后患者,因此需要进一步调查.
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