炎症性肠病患者的刺激性肠综合征:患病率,病因和治疗
David J Gracie1, Alexander C Ford1,2
1Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, United Kingdom.
Gastroenterology & hepatology
|September 2, 2025
概括
许多炎症性肠病 (IBD) 患者会出现类似于刺激性肠综合征 (IBS) 的持续性胃肠症状. 针对大脑-肠轴可以改善这些人的症状和生活质量.
科学领域:
- 胃肠病学
- 神经胃肠病学
- 心理胃肠病学
背景情况:
- 很大一部分患有静止性炎症性肠病 (IBD) 的患者报告了类似于刺激性肠综合征 (IBS) 的持续性胃肠症状.
- 这些IBS类型的症状与心理困扰,生活质量下降和医疗保健使用量的增加有关.
- 大脑-肠轴与中枢神经系统和胃肠功能之间的关系有关,可能会调解这些症状.
研究的目的:
- 对静止性IBD患者的IBS类症状的流行,影响,病因和治疗进行审查.
- 突出脑肠轴在IBD病理生理学和症状报告中的作用.
- 强调在患者群体中进行临床试验的必要性.
主要方法:
- 对观察性研究和现有证据的文献审查.
- 在IBD中分析情绪,炎症和肠-大脑轴功能之间的关系.
- 检查潜在的治疗策略,包括饮食操纵,神经调节剂和行为疗法.
主要成果:
- 观察数据表明IBD的情绪和炎症活动之间存在联系,这强调了脑肠轴的作用.
- 目前对IBD患者的脑肠轴治疗的证据有限.
- 结合IBD治疗和脑肠轴干预的综合管理方法显示出有前途.
结论:
- 患有静止性IBD的患者经常出现IBS类型的症状,影响他们的健康.
- 针对大脑-肠轴, 与IBD治疗一起, 提供缓解这些症状的潜在策略.
- 需要进一步的研究和临床试验来验证IBD脑肠轴的治疗方法.
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