患有肥胖症的老年人中甘油三指数与全因死亡率之间的关系
Qiong Huang1,2, Xiuben Du3, Wenwei Ouyang4,5
1Guangzhou University of Chinese Medicine, Guangzhou, China.
Metabolism open
|September 2, 2025
概括
甘油三糖 (TyG) 指数显示了与老年肥胖症 (SO) 死亡率的U型联系. 非常低的TyG指数和非常高的TyG指数都与全因死亡风险的增加有关.
科学领域:
- 老年学
- 代谢健康
- 流行病学
背景情况:
- 老年人的肥胖症 (SO) 结合了低肌肉量和高脂肪,增加了健康风险.
- 胰岛素抵抗的标志物甘油三指数 (TyG) 与代谢功能障碍有关.
- 在SO患者中,TyG指数对死亡率的预测作用尚不清楚.
研究的目的:
- 调查TyG指数与老年肥胖患者全因死亡率之间的关联.
- 探索TyG指数如何预测SO群体中不同年龄组的死亡风险.
主要方法:
- 使用了30137名成年人 (1999-2018) 的SO趋势和706名参与者 (NHANES 1999-2004) 的死亡率分析数据.
- 根据2014年FNIH标准定义了肉,并使用了考克斯回归和立方线来进行统计分析.
- 检查了TyG指数水平与全因死亡率之间的关系,包括按年龄和死亡原因分类的子组分析.
主要成果:
- 在SO患者中观察到TyG指数与全因死亡率之间存在U型关联.
- 与参考组 (TyG组3) 相比,低 (TyG组1) 和高 (TyG组5) 的TyG指数水平与显著增加的死亡风险有关.
- 年龄特定的分析表明,老年人 (≥70岁) 死亡风险模式发生变化,高TyG水平 (第5组) 与心血管疾病死亡率增加有关.
结论:
- 在患有肥胖症的个体中,TyG指数显示了与全因死亡率的U型关联.
- 这两个极端的TyG指数 (低和高) 都与死亡风险增加有关,突出显示了复杂的关系.
- 考虑到与年龄相关的变化,专注于代谢健康的定制策略对于减轻这一群体的死亡风险至关重要.
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