饮食习惯和骨质疏松骨折风险:使用大规模索赔数据的回顾性队列研究
Hiroki Nakajima1, Yuichi Nishioka1,2, Yuko Tamaki1
1Department of Diabetes and Endocrinology, Nara Medical University, Nara 634-8521, Japan.
Journal of the Endocrine Society
|September 2, 2025
概括
跳过早餐和晚餐与骨质疏松性骨折的风险增加有关. 这项大规模的研究强调了正确的饮食时间对骨健康的重要性.
科学领域:
- 流行病学
- 骨健康
- 生活方式医学
背景情况:
- 生活方式因素 (运动,酒精,吸烟) 与骨质疏松性骨折风险之间存在确定的联系.
- 特定的饮食习惯与骨质疏松性骨折风险之间的关联仍然不太清楚.
研究的目的:
- 研究包括饮食模式在内的各种生活习惯与骨质疏松性骨折的发生率之间的关系.
- 确定可能导致骨质疏松骨折或防止骨折的特定饮食习惯.
主要方法:
- 使用健康检查数据和日本索赔数据库 (DeSC) 分析了超过927,000名20岁以上的人群.
- 通过问卷评估生活习惯,并记录骨质疏松性骨折 (部,前臂,脊椎,部) 作为结果.
- 考克斯的比例危险模型用于计算生活方式因素的调整危险比率,控制常规风险因素.
主要成果:
- 吸烟 (HR 1.11) 和不吃早餐 (HR 1.18) 与骨质疏松性骨折的风险显著增加有关.
- 晚餐 (HR1. 08) 也显示风险增加,而每日饮酒 (HR0. 91) 和快速步行 (HR0. 84) 与风险降低有关.
- 在这一群体中,运动习惯和充足的睡眠与骨质疏松性骨折风险没有显著关联.
结论:
- 跳过早餐和晚餐独立地与骨质疏松性骨折的风险增加有关.
- 这些发现强调了饮食时间对骨健康和骨折预防的潜在影响.
- 这项研究对饮食习惯作为骨质疏松性骨折的可修改风险因素提供了新的见解.
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