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Updated: Sep 9, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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一种Galbulimima类化合物的双向修饰识别了选择性阿片类联体

Florian Martin Zielke1, Stone Woo1,2, Samuel Kasmali1,2

  • 1Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.

ACS central science
|September 2, 2025
PubMed
概括

研究人员将新型阿片类抗体GB18优化为选择性卡帕阿片类受体 (KOR) 激动剂. 这些化合物有望开发具有改善副作用的新疼痛疗法.

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