对外化谱和自杀风险的多变量基因组研究
Peter B Barr1,2,3,4, Mallory Stephenson5, Holly E Poore6,7
1VA New York Harbor Healthcare System, Brooklyn, NY.
medRxiv : the preprint server for health sciences
|September 2, 2025
概括
外向化障碍的特征是行为失禁, 与自杀行为有显著的联系. 这项研究强调了外表化特征与自杀风险之间的遗传和表型联系,强调了需要更多的临床关注.
科学领域:
- 精神病学
- 遗传学
- 神经科学
背景情况:
- 自杀的想法和行为源于复杂的机制,包括在外部化疾病中观察到的行为抑制.
- 之前的研究表明外表化疾病和自杀企图之间存在很大遗传重叠.
- 自杀与内化障碍之间的关系得到了更多的关注.
研究的目的:
- 调查一系列自杀现象与外化障碍之间的共发生.
- 使用百万退伍军人计划 (MVP) 数据估计外部化潜在基因组因子 (MVP-EXT).
- 检查外化特征与自杀结果之间的遗传重叠和潜在的表型关联.
主要方法:
- 在MVP数据上利用基因组结构方程建模 (GenomicSEM) 来导出外部化的基因组因子 (MVP-EXT).
- 评估遗传相关性,多基因分数和死后脑组织中的基因丰富.
- 检查了MVP队列中的表型外部化得分和自杀死亡之间的潜在关联.
主要成果:
- 确定了155个与欧洲和非洲MVP参与者的外部化特征相关的位置.
- MVP-EXT与先前的外部化因素和跨祖先的自杀企图有很强的遗传关联.
- 外化多基因分数预测了独立群体的自杀想法和尝试;表型外化预测了自杀死亡.
结论:
- 外向化障碍是自杀相关行为的一个重要,但往往被忽视的风险因素.
- 遗传和现象特征与自杀之间的联系很强大, 需要进一步调查.
- 增加临床关注行为外部化作为潜在的自杀前例对于预防工作至关重要.
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