液体等离子体与解等离子体:在储存期间跟踪凝血因子活动变化
medRxiv : the preprint server for health sciences
|September 2, 2025
概括
液体血 (LQP) 的保质期比解血 (TP) 的保质期更长. LQP显示了关键凝血因子的可比水平,使其成为关键护理场景的可行替代方案.
科学领域:
- 输血医学
- 血液学
- 生物化学
背景情况:
- 液体血 (LQP) 提供了一个更长的保质期替代解血 (TP) 的新兴输血.
- 评估LQP凝血因子的稳定性和活性对于其临床应用至关重要.
研究的目的:
- 在LQP中测量纤维素,蛋白C,蛋白S,FV,FVII和FVIII活性.
- 量化存储期间LQP中的这些因素水平的变化.
- 将LQP因子活动与TP进行比较.
主要方法:
- 在第15天,第26天和第27天测量了凝血因子活动的LQP (n=26),在第5天测量了TP (n=24).
- 用贝叶斯统计模型来比较因子活动并评估与存储相关的变化.
主要成果:
- 在第26天 (LQP26) 的纤维素和蛋白C活性与第5天 (TP5) 的TP相当.
- 与TP5相比,LQP26中的FV,FVII和FVIII活动略低.
- 在LQP26中,蛋白S活性明显低于TP5 (64. 9%).
- 从第15天到第26天,FVII活动下降,而其他因素保持稳定.
结论:
- 除了较低的蛋白S水平,LQP与紧急使用的TP具有相似的纤维素,蛋白C,FV,FVII和FVIII活性.
- 由于其延长的保质期和充足的因子水平,LQP是紧急输血和大规模输血方案的可行替代方案.
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