中性细胞与淋巴细胞的比率,血动脉指数和心血管疾病发病率之间的关联
Hongxin Cheng1,2, Wen Zhong1,2, Hanbin Li1,2
1Department of Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
中性粒细胞与淋巴细胞比率 (NLR) 和动脉动脉指数 (AIP) 的较高水平与心血管疾病 (CVD) 有关. 结合NLR和AIP可以更好地预测心脏病发病率,建议进行联合预防监测.
科学领域:
- 心血管医学
- 炎症生物标志物
- 脂肪新陈代谢
背景情况:
- 心血管疾病 (CVD) 的发病率正在全球上升.
- 诸如中性细胞与淋巴细胞的比率 (NLR) 和血脂指数 (如血动脉指数 (AIP)) 等炎症标志物与心血管疾病有关.
- 了解NLR和AIP在CVD中的不同和联合作用至关重要.
研究的目的:
- 调查NLR和AIP与心脏病发病率的独立和联合关系.
- 评估NLR和AIP对心血管疾病的预测效果,单独或组合.
主要方法:
- 使用了13,184个人的数据,使用复杂的调查设计和样本权重.
- 从周围血液计数计算的中性细胞与淋巴细胞比率 (NLR).
- 使用日志转换的甘油三和HDL-C水平计算的血动脉指数 (AIP).
主要成果:
- 增加的NLR和AIP独立地与心血管疾病风险增加有关.
- 与最低四分位数相比,AIP和NLR的最高四分位数显示CVD的几率比率明显高.
- 高NLR和AIP的组合显示出协同作用,对心血管疾病的几率比较高,预测准确度提高 (AUC: 0. 629).
结论:
- 这项研究表明NLR和AIP对心血管疾病的发展具有联合影响.
- 监测和管理NLR和AIP水平可能为心血管疾病预防策略带来临床益处.
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