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Updated: Sep 9, 2025

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强迫症中的执行控制:ENIGMA-OCD联盟基于任务的功能神经成像数据的全球大分析

Nadza Dzinalija, Ilya M Veer, H Blair Simpson

bioRxiv : the preprint server for biology

|September 2, 2025

概括

强迫症患者在认知任务中表现出较弱的执行控制区域大脑激活和增加的默认模式网络活动. 这表明强迫症患者的目标行为受损.

科学领域:

神经科学
精神病学
认知心理学

背景情况:

强迫症与执行功能障碍和神经回路活动的改变有关,
之前的研究表明强迫症患者的执行功能受损.

研究的目的:

在大量强迫症患者中调查执行控制任务中的神经激活模式.
确定强迫症患者与健康对照者在执行功能任务中的大脑活动差异.

主要方法:

在15项fMRI任务中对475名强迫症患者和345名健康对照者的个人数据进行了大规模分析.
使用HALFpipe和多层贝叶斯模型分析区域和全脑效应的统一数据处理.

主要成果:

强迫症患者在关键执行控制区域的激活显著较弱,包括背侧前额叶皮质,前额叶,前额叶和下额叶.
与对照人群相比,强迫症患者在执行职能任务中在默认模式网络内激活更强烈.
很少有证据表明与疾病发病,严重程度或药物状况相关的差异激活.

结论:

首次对强迫症执行功能的fMRI研究进行大规模分析,
研究结果表明,在强迫症患者执行任务时,默认模式网络可能无法适当地关闭,从而导致认知缺陷.

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