在COVID-19的急性后续症期间持续的免疫失调体现在针对信封和核囊蛋白的抗体中
Marcin Kwissa1,2, Manikannan Mathayan2,3, Satyajeet S Salunkhe2,3
1Department of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL, USA.
bioRxiv : the preprint server for biology
|September 2, 2025
概括
长期COVID (PASC) 涉及持续的免疫失调,包括抗体反应的改变和免疫细胞的升高. 这种免疫失衡持续至少六个月,影响各种长期COVID症状的患者.
科学领域:
- 免疫学
- 传染性疾病
- 病毒学
背景情况:
- SARS-CoV-2 感染后急性后果 (PASC) 或长期COVID是一个重大的健康问题.
- 免疫失调是PASC的已知特征,但其长期发展轨迹尚不清楚.
研究的目的:
- 调查PASC患者在六个月内免疫失调的持续性.
- 在PASC患者和康复期患者之间比较免疫特征,包括抗体反应,免疫细胞群和细胞因子水平.
主要方法:
- 长度评估SARS-CoV-2特异性抗体标位 (IgG,类切换偏差).
- 通过 CyTOF 分析对外围免疫细胞群 (T 毛囊辅助细胞,MAIT 细胞) 进行分析.
- 测量自身抗体和循环中的细胞因子 (LIF,IL-11,Eotaxin-3,HMGB-1).
主要成果:
- PASC 参与者对 SARS-CoV-2 包裹和核体蛋白质的IgG 标位持续升高.
- 在PASC患者中观察到较低的IgG反应与IgG1/IgG3偏差.
- 血液循环中的T毛囊辅助细胞和MAIT细胞与高抗包膜IgG标位相关.
- 在PASC患者中,血清细胞因子概况增加,自身抗体水平增加.
结论:
- 在PASC中,免疫失调持续至少六个月.
- 结果表明潜在的治疗点包括病毒持久性,抗体产生和自身免疫力.
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