相关实验视频

Updated: Sep 9, 2025

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

通过平面细胞极性发出L1CAM信号,在肺腺癌中产生SOX2

Jin Suk Park, Yasemin Kaygusuz, Carson Kenum

bioRxiv : the preprint server for biology

|September 2, 2025

概括

肺癌细胞通过L1CAM和平面细胞极性信号获得胎儿样的原始特征,驱动转移. 这种途径维持了瘤启动能力,并为转移性肺腺癌提供了新的治疗点.

科学领域:

癌症学
细胞生物学
分子生物学

背景情况:

癌症的进展涉及塑性过渡,产生具有转移潜力的原始状态.
在肺腺癌 (LUAD) 中,这些转移原体的出现和持续的机制尚未完全理解.

研究的目的:

阐明在LUAD中导致SOX2阳性 (SOX2+) 转移的过程.
确定细胞粘附分子L1CAM在促进SOX2+ LUAD原始状态中的作用.

主要方法:

研究L1CAM表达在LUAD瘤侵袭前线和转移.
检查了L1CAM在平面细胞极性 (PCP) 复合组合和非正规WNT信号中的作用.
评估了c-Jun和CHD1在驱动SOX2表达中的合作功能.

主要成果:

在侵袭前端的LUAD细胞和转移中表达L1CAM,标记再生表皮原体.
通过促进PCP复合体的组装,L1CAM促进SOX2+ LUAD的原始状态.
与CHD1相关的PCP信号激活了c-Jun,这导致SOX2表达和转移活动.

结论:

L1CAM和PCP信号对于产生SOX2+LUAD原体,维持瘤启动和再生能力至关重要.
这个L1CAM-PCP-c-Jun-CHD1轴代表了治疗转移性LUAD的潜在治疗目标.

更多相关视频

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

相关概念视频

Cancer Cell Migration through Invadopodia

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...