脊椎动物中Cajal-Retzius细胞的演化来自Tp73+神经元的古老类
Elias Gumnit1, Giacomo Gattoni1, Jamie Woych1
1Department of Biological Sciences, Columbia University, New York, NY, USA.
bioRxiv : the preprint server for biology
|September 2, 2025
概括
研究人员在脊椎动物中发现了保留的Tp73表达神经元,这表明Cajal Retzius (CR) 细胞和外部形细胞 (ETC) 从嗅觉处理细胞进化.
科学领域:
- 神经科学
- 发育生物学
- 进化生物学
背景情况:
- 在哺乳动物大脑皮层发育过程中,Cajal Retzius (CR) 细胞至关重要.
- 在非哺乳动物物种中识别同类细胞类型是具有挑战性的.
研究的目的:
- 通过研究脊椎动物物种中的Tp73表达神经元来研究CR细胞的进化起源.
- 确定Tp73表达是否是CR细胞样群的保存标记.
主要方法:
- 对,,斑马鱼和小滑板的基因表达数据 (Tp73) 的比较分析.
- 对表达Tp73的神经元进行转录.
- 检查Tp73+神经元的空间分布.
主要成果:
- 表达TP73的神经元在脊椎动物中表现出保存的空间分布和转录基因特征.
- 在脊椎动物中,CR细胞和外部状细胞 (ETC) 分享关键转录因子表达 (Tp73,Lhx1,Lhx5,Ebf3,Nr2f2).
- 这些发现确定了CR细胞和ETC作为姐妹细胞类型.
结论:
- CR细胞和ETCs很可能来自早期脊椎动物的祖先嗅觉处理细胞.
- CR细胞在发育信号中逐渐发展出特殊的作用,超出了它们的嗅觉起源.
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