前列腺癌尿道蛋白质的特征是依赖于祖先的免疫和预后效应
Annie Ha1,2, Jaron Arbet3,4, Zhuyu Qiu3,4
1Department of Medical Biophysics, University of Toronto, Toronto, Canada.
bioRxiv : the preprint server for biology
|September 2, 2025
概括
在黑人和白人前列腺癌患者之间发现了尿路生物标志物差异. 这些发现强调在开发前列腺癌新诊断工具时需要考虑种族和祖先.
科学领域:
- 生物化学
- 癌症学
- 尿道病学
背景情况:
- 尿液作为一种有价值的非侵入性生物标志物,用于监测健康和疾病,包括生殖尿路癌症.
- 尿液的组成受遗传和生活方式因素的影响,在不同的人群中存在差异.
- 非洲血统的男性患前列腺癌的风险更高, 但对尿路生物标志物的影响尚不清楚.
研究的目的:
- 在本地化前列腺癌患者中研究尿蛋白的种族差异.
- 确定种族/祖先是否影响与前列腺癌侵袭性相关的尿路生物标志物.
主要方法:
- 从329位局部前列腺癌患者 (135位白人,194位黑人) 的尿蛋白质的定量分析.
- 对年龄,前列腺特异抗原 (PSA) 和临床格里森评分 (cISUP) 进行统计分析.
主要成果:
- 鉴定了110种蛋白质, 黑人和白人患者之间存在显著差异.
- 观察到免疫路径的失调.
- 与匹配的白人患者相比,黑人患者的尿蛋白显示出更多的侵袭性癌症指标.
结论:
- 在前列腺癌患者中,种族和血统显著影响尿蛋白质谱.
- 考虑与种族和祖先相关的差异对于开发精确的尿路生物标志物至关重要.
- 为了有效监测疾病,未来的生物标志物开发必须考虑人群特异性变异.
更多相关视频
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.2K
12:23Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
Published on: August 2, 2018
12.2K
相关概念视频
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Nursing Assessment of the Genitourinary System I: Health History
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
