个体差异影响大脑中的概念表现
Matteo Visconti di Oleggio Castello1,2, Tom Dupré la Tour1, Jack L Gallant1,2
1Helen Wills Neuroscience Institute, University of California, Berkeley; Berkeley, CA 94720, USA.
bioRxiv : the preprint server for biology
|September 2, 2025
概括
科学家们开发了一种新的统计框架来测量个体大脑在概念表现上的差异. 这种方法揭示了个体特定的大脑偏差,为精确神经科学和针对认知障碍的个性化医疗铺平了道路.
科学领域:
- 认知神经科学
- 神经成像
- 个人差异
背景情况:
- 在认知神经科学中很难衡量这些差异.
- 这限制了对认知障碍的精准医学.
- 现有的方法难以捕捉特定人的功能性大脑表现.
研究的目的:
- 开发一个新的统计框架来测量和解释功能性大脑表现的个体差异.
- 描述不同个体在他们的大脑中如何表现相同的概念.
- 建立一个精确神经科学的新范式.
主要方法:
- 用功能磁共振成像 (fMRI) 测量24名参与者听故事的脑活动.
- 使用编码模型来解码fMRI数据中的概念表示.
- 进行了统计分析,以确定这些表现中的系统的个体差异.
主要成果:
- 尽管有相同的刺激,但在概念性大脑表现中观察到有系统的,人为特异性的偏差.
- 在与社会信息处理相关的大脑区域中,个体变异性最为明显.
- 这些差异与感官输入和个人信念/经验的整合有关.
结论:
- 大脑的概念表现的个体差异是系统的和可测量的.
- 开发的框架可以研究个体特定的功能大脑图.
- 这项研究为精密神经科学和fMRI应用在认知障碍的精密医学提供了基础.
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