相关实验视频

Updated: Sep 9, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K

在肺腺癌中,MYC 和表皮转移到介质细胞转移 (EMT) 独立预测昼夜节律障碍

Jamison B Burchett, Aslihan Ambeskovic, McKayla Ford

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    概括

    肺癌中的分子昼夜钟受损与MYC表达和细胞状态有关. 在腺癌中,高MYC和中细胞特征都独立地影响昼夜节律的破坏.

    更多相关视频

    Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures06:53

    Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

    Published on: November 11, 2016

    8.4K
    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters10:38

    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

    Published on: September 27, 2012

    22.6K

    相关概念视频

    Circadian Rhythms and Gene Regulation02:19

    Circadian Rhythms and Gene Regulation

    The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
    4.1K
    mTOR Signaling and Cancer Progression03:03

    mTOR Signaling and Cancer Progression

    The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
    The mTOR pathway or the...
    3.9K
    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
    4.6K
    Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

    Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

    Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
    The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
    123