Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
Aging01:26

Aging

179
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
179
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.3K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Loss of the lncRNA <i>SOX1-OT</i> promotes p53-dependent cell-cycle arrest in astrocytes.

bioRxiv : the preprint server for biology·2026
Same author

Translational Insights into Exercise-Induced Protective Adaptations in 5XFAD Mice and Middle-Aged Amateur Sportsmen.

Antioxidants (Basel, Switzerland)·2026
Same author

In-situ inference of the thermoacoustic properties of an industrial combustion systema).

The Journal of the Acoustical Society of America·2026
Same author

Learning the relationship between operating condition and flame response from acoustic dataa).

The Journal of the Acoustical Society of America·2026
Same author

The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.

NPJ Parkinson's disease·2026
Same author

The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies.

Molecular psychiatry·2026

相关实验视频

Updated: Sep 9, 2025

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
06:24

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

3.6K

蛋白转录组重编程和资源重新分配决定了老化的哺乳动物大脑

Nisha Hemandhar-Kumar, Verena Kluever, Svenja V Kaufmann

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    概括

    衰老的大脑显示出影响蛋白质功能和细胞过程的分子变化, 增加神经退行风险. 这项研究揭示了正常大脑衰老与疾病之间的关键差异,

    更多相关视频

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
    08:52

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

    Published on: April 6, 2022

    3.6K
    Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
    08:38

    Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

    Published on: May 22, 2021

    5.2K

    相关实验视频

    Last Updated: Sep 9, 2025

    Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
    06:24

    Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

    Published on: October 7, 2021

    3.6K
    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
    08:52

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

    Published on: April 6, 2022

    3.6K
    Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
    08:38

    Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

    Published on: May 22, 2021

    5.2K

    科学领域:

    • 神经科学
    • 分子生物学
    • 老年学

    背景情况:

    • 大脑衰老是神经退行性疾病的重要危险因素.
    • 导致大脑衰老和神经退行的分子机制尚未完全理解.

    研究的目的:

    • 通过整合性蛋白质转录基因方法研究大脑衰老的分子特征.
    • 将生理衰老中的分子变化与早衰和神经退行模型进行比较.

    主要方法:

    • 对老鼠大脑进行综合性蛋白质转录组分析.
    • 评估蛋白质聚合,mRNA重新定位和比较蛋白质组学.
    • 通过八种过早衰老和神经退化模型进行分析.

    主要成果:

    • 在生理衰老过程中确定了突触维护和能量分配的动态变化.
    • 由于60S核糖体子单元的聚合,观察到线粒体复合I蛋白减少而没有mRNA补偿和翻译效率受损.
    • 揭示了生理衰老和神经退行性病理之间的关键相似之处和差异.

    结论:

    • 分子衰老涉及蛋白质生化特性,线粒体功能和翻译效率的变化.
    • 了解这些衰老机制可以了解导致神经退化的途径.
    • 大脑衰老和分子图谱项目 (BrainAging-MAP) 为大脑衰老研究提供了一个可访问的资源.