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Updated: May 5, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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主要导致MLC的突变改变小鼠皮层发育中的星体细胞中的hepaCAM亚细胞局部和蛋白质相互作用体

Robert W Lewis1, Breana C Dogan1, Madelyn G Coble1

  • 1Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

带有皮下囊 (MLC) 的大脑脑白内障与GlialCAM突变有关. 这项研究揭示了这些突变如何破坏GlialCAM

关键词:
星球细胞发展医疗药物血清变异症蛋白质组学

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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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