宿主-微生物组相互性驱动在冬眠期间的尿素碳回收和乙生成
bioRxiv : the preprint server for biology
|September 2, 2025
概括
冬眠中的松鼠利用肠道微生物从尿素中获取碳, 这种尿素碳回收 (UCS) 过程支持宿主微生物在冬季禁食期间的能量需求.
科学领域:
- 微生物代谢和宿主微生物相互作用
- 哺乳动物的冬眠和代谢适应
- 在极端环境中营养物质的救援途径
背景情况:
- 冬眠使哺乳动物能够通过和禁食在冬季的短缺中生存.
- 禁食消除了饮食中的碳,
- 了解冬眠者如何保持碳平衡至关重要.
研究的目的:
- 调查冬眠中的13层地松鼠中尿素碳回收 (UCS) 的机制.
- 确定肠道微生物从尿素中回收碳的作用.
- 阐明UCS如何在冬眠期间支持宿主和微生物的能量代谢.
主要方法:
- 肠道微生物组组成和功能的基因组分析.
- 稳定同位素追踪可以追踪从尿素到酸的碳流.
- 在冬眠和活跃的松鼠中测量酸盐吸收和氧化率.
主要成果:
- 确定了两步过程,其中涉及尿素溶解和乙酸性细菌将尿素碳转化为乙酸盐.
- 在冬眠期间与活跃季节相比,尿素碳在酸盐中增强.
- 在冬眠期间增加了宿主乙酸的吸收和氧化, 支持能源需求.
结论:
- 尿素碳回收 (UCS) 是一个关键的适应,使冬眠松鼠能够在禁食期间克服碳限制.
- 通过提供酸盐和支持粘素降解,UCS促进宿主-微生物互惠.
- 这种微生物与宿主之间的相互作用凸显了禁食哺乳动物获得营养的广泛策略.
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