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相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Background and Environment Affect Phenotype02:27

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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相关实验视频

Updated: Sep 9, 2025

Dissection and Downstream Analysis of Zebra Finch Embryos at Early Stages of Development
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性如何塑造歌鸟大脑中的转录组进化

Isaac Miller-Crews1, Sara E Lipshutz1,2, Ben Fulton1,3

  • 1Department of Biology, Indiana University, Bloomington, IN, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

在歌鸟大脑中性别偏差基因表达的进化速率被量化. 性偏差基因表达在Z染色体上发展得更快,并受到化行为的影响.

关键词:
行为大脑一个进化性别问题一个歌鸟转录组

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科学领域:

  • 进化生物学
  • 基因组学
  • 神经科学

背景情况:

  • 基因表达的性别差异很普遍,但它们的进化动态不明.
  • 量化性偏差基因表达的进化速率对于理解性选择和二态性至关重要.

研究的目的:

  • 测量歌鸟大脑中性别偏差基因表达的进化速率.
  • 研究染色体位置和生殖生态对基因表达偏差的演变的影响.

主要方法:

  • 在CAGEE软件包中开发了基因表达进化的新进化模型.
  • 分析了来自10种歌鸟的脑基因表达数据,
  • 在Z链接基因和自体之间比较性偏差基因表达的进化率.

主要成果:

  • 性偏差基因表达在Z染色体上演变的速度是自体相比的两倍.
  • 性别偏差的基因表达进化的速度在具有强制性巢行为的血统中加快.
  • 性别平衡的基因不会以较慢的速度进化, 挑战了平衡选择的假设.

结论:

  • 在性偏差基因表达的快速演变中,Z染色体起着重要作用.
  • 生态因素,如化策略,可以推动大脑中性别特异性基因表达模式的演变.
  • 新的计算工具有助于研究基因表达进化及其与表型分歧的关系.