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Updated: Sep 9, 2025

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
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对RILPL1与TMEM55B的结合的结构基础显示了通过保存的TBM图案进行适配器组装的溶酶体平台

Dieter Waschbüsch1, Prosenjit Pal2, Raja S Nirujogi2

  • 1School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

在VPS35和LRRK2激酶的突变导致Rab GTPase高酸化,形成信号复合体. TMEM55B 作为 lysosomal 膜的中心枢纽, 招募 RILPL1 和其他蛋白质, 揭示新的调节网络.

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