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Updated: Sep 9, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

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时间分辨率晶体学揭示了N-RAS和瘤突变G12C,G12V和Q61L的GTP水解机制

Guowu Lin1, Paola Zinser-Peniche1, Xiaohong Zhou1

  • 1Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

研究人员可视化了RAS蛋白中的GTP水解,揭示了癌症相关突变的独特反应机制. 这种对GTPase活性的结构洞察力可以指导针对特定中间状态的新癌症药物发现.

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Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells10:27

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Ras is a...
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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
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