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Updated: Sep 9, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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在内分泌疗法耐药乳腺癌中,胺诱导的内分泌网膜压力是可向的脆弱性

Purab Pal1, Shweta Chitkara2, Godwin K Sarpey1

  • 1Department of Physiology and Biophysics, University of Illinois Chicago, IL, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

乳腺癌的内分泌疗法耐药性包括胺的减少和对胺诱导的细胞死亡的敏感性增加. 陶胺通过PERK激活内质网膜应激 (EnRS) 途径,导致抵抗性细胞的细胞死亡,特别是通过TRAM1相互作用.

关键词:
陶化物与胺相互作用的蛋白质内分泌疗法耐药性细胞内膜网应力乳腺癌的发明美国一个TRAM1

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