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相关概念视频

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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哺乳动物基因程序计算机辅助设计的计算框架

Kathleen S Dreyer1,2, Anh V Nguyen3, Gauri G Bora1,2

  • 1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.

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概括
此摘要是机器生成的。

这项研究引入了计算机辅助设计框架,以加速哺乳动物细胞中合成遗传程序的创建. 新的计算方法可以更快地设计和实验验证复杂的遗传电路.

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科学领域:

  • 合成生物学
  • 计算生物学
  • 哺乳动物细胞工程

背景情况:

  • 设计哺乳动物细胞的遗传程序是复杂的,因为部分限制和人口效应.
  • 对于复杂的函数, 代模拟和实验是耗时的.

研究的目的:

  • 为哺乳动物遗传程序开发计算机辅助设计框架.
  • 为了加快合成生物学家的设计实施周期.

主要方法:

  • 使用特征部分和动态系统模型库开发基于遗传算法的框架.
  • 使用有生物约束规则的定向图表来探索监管网络.
  • 评估了放大器,信号调节器和脉冲发生器设计问题的框架性能.

主要成果:

  • 该框架成功地确定了各种复杂度的最佳电路设计.
  • 实验验证证了预测电路设计的可行性.
  • 证明了部分特征对预测设计的重要性.

结论:

  • 开发的框架加速了哺乳动物遗传程序的设计和实施.
  • 建立合成生物学设计的通用方法.
  • 突出了捕捉哺乳动物特异性行为和种群影响的计算工具的需要.