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Updated: Sep 9, 2025

Capturing Chromosome Conformation Across Length Scales
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Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

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聚合物衍生的距离处罚可以从单细胞基因组数据中改善染色体相互作用的预测

Luca Schlegel1, Fabio Gómez Cano2, Alexandre P Marand2

  • 1Plant Epigenomics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, 85354, Germany.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
概括

我们开发了一种基于聚合物物理的方法来纠正3D基因组相互作用数据的高估, 显著提高了植物长距离染色质接触的准确性.

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Genome-wide Mapping of Protein-DNA Interactions with ChEC-seq in Saccharomyces cerevisiae10:43

Genome-wide Mapping of Protein-DNA Interactions with ChEC-seq in Saccharomyces cerevisiae

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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin10:05

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin

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相关概念视频

Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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