相关实验视频

Updated: Sep 9, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

随着寿命的推移,白质微观结构的变化:纵向扩散MRI研究的元分析

Karis Colyer-Patel^1,2, Jalmar Teeuw^1,3, Vivien Maes³

¹University Medical Center Utrecht, UMC Brain Center, Department of Psychiatry, Utrecht, The Netherlands.

bioRxiv : the preprint server for biology

|September 2, 2025

概括

白质完整性,以分数异构度 (FA) 衡量,在年轻时增加,在中年时下降. 遗传因素会影响这些白质的变化.

科学领域:

神经科学
人类发展
遗传学

背景情况:

白质可以促进大脑的交流.
从扩散MRI中得到的微分异构 (FA) 量化了白质微观结构.
它与神经效率,运动和认知功能有关.

研究的目的:

在整个生命周期中系统地审查白质FA的纵向变化.
研究遗传因素对随着时间的推移而发生的FA变化.

主要方法:

在Medline,PsycInfo和EMBASE进行系统的文献搜索.
包括在整个生命周期中测量FA的研究.
进行元回归分析以建模与年龄有关的FA变化.

主要成果:

在童年和青春期增加FA,在成年早期稳定 (20-35).
从36岁到50岁,FA显著下降,在51岁到61岁之间停滞不前,然后慢慢下降到77岁.
遗传性影响了发育过程中的局部FA变化;像APOE,HTT,MAPT这样的基因与老化中的FA衰退有关.

结论:

白物质的微观结构在整个生命过程中发生变化,具有不同的发育和衰老轨迹.
新出现的证据表明遗传因素会随着时间的推移影响个体的白质变化.

关键词:

在GWAS 大脑候选基因扩散张力成像分数异构性在基因上遗传性纵向的进行元分析网络连接系统审查白色物质

更多相关视频

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

相关概念视频

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...